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Acetaminophen toxicity is also common in children, although adults account for most severe and fatal cases

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4 Metabolic interactions in the hepatocellular carcinoma tumor microenvironment 4.1 Metabolic crosstalk between hepatic stellate cells and hepatocellular carcinoma cells Cancer cells maintain an alkaline intracellular environment by undergoing aerobic glycolysis, which generates a large amount of protons that are transported to the extracellular space through upregulation of H+ transport proteins